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Relationships Between Building Design, Management System and Dairy Cow Welfare
- V A Bowell, L J Rennie, G Tierney, A B Lawrence, M J Haskell
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- Journal:
- Animal Welfare / Volume 12 / Issue 4 / November 2003
- Published online by Cambridge University Press:
- 11 January 2023, pp. 547-552
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As part of a larger on-farm dairy cow welfare and behaviour project, data were collected from 22 commercial dairy farms over two winters (2000-2001 and 2001-2002). A further winter of farm sampling will complete the project (2002-2003), with five types of housing and production systems being assessed: high-, medium- and low-milk-production herds with cubicle housing, high-production herds with zero grazing and cubicle housing, and medium-production herds with straw courts. All cows in one early or mid-lactation group from each farm were observed. For the current analysis, locomotion, cleanliness and body condition were scored for the group, and an audit of building quality was carried out. Analysis of the available data shows that some aspects of building design affect the welfare of dairy cows. A positive correlation was found between mean body condition score of the cows and mean locomotion score (P = 0.047). Body condition score correlated negatively with the number of cows in the group (P = 0.049). Negative correlations were found between locomotion score and the ratio of cubicles to cows (P = 0.033) and between the size of cubicles and leg cleanliness (P = 0.012). Trends were also seen in the relationships between farm type and locomotion score (P = 0.048), production level and locomotion score (P = 0.074) and cow cleanliness and cubicle size (P = 0.061). These results indicate that the quality of the housing and the management system can affect cow welfare. These measures may be useful to include in on-farm welfare assessment schemes.
Farm animal welfare: assessing risks attributable to the prenatal environment
- KMD Rutherford, RD Donald, G Arnott, JA Rooke, L Dixon, JJM Mehers, J Turnbull, AB Lawrence
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- Journal:
- Animal Welfare / Volume 21 / Issue 3 / August 2012
- Published online by Cambridge University Press:
- 01 January 2023, pp. 419-429
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An ever-expanding scientific literature highlights the impact of the prenatal environment on many areas of biology. Across all major farmed species, experimental studies have clearly shown that prenatal experiences can have a substantial impact on outcomes relevant to later health, welfare and productivity. In particular, stress or sub-optimal nutrition experienced by the mother during pregnancy has been shown to have wide-ranging and important effects on how her offspring cope with their social, physical and infectious environment. Variation in the conditions for development provided by the reproductive tract or egg, for instance by altered nutritional supply or hormonal exposure, may therefore explain a large degree of variation in many welfare- and productivity-relevant traits. The scientific literature suggests a number of management practices for pre-birth/hatch individuals that could compromise their later welfare. Such studies may have relevance for the welfare of animals under human care, depending on the extent to which real life conditions involve exposure to these practices. Overall, the findings highlight the importance of extending the focus on animal welfare to include the prenatal period, an aspect which until recently has been largely neglected.
P.002 Saccade parameters reveal cognitive impairment and differentially associate with cognitive domains across neurodegenerative diseases
- HC Riek, BC Coe, DC Brien, J Huang, A Abrahao, S Arnott, D Beaton, M Binns, S Black, M Borrie, L Casaubon, D Dowlatshahi, E Finger, C Fischer, A Frank, M Freedman, D Grimes, A Hassan, M Jog, S Kumar, D Kwan, A Lang, J Lawrence Dewar, B Levine, W Lou, J Mandzia, C Marras, M Masellis, P McLaughlin, J Orange, S Pasternak, A Peltsch, B Pollock, T Rajji, A Roberts, D Sahlas, G Saposnik, D Seitz, C Shoesmith, T Steeves, S Strother, S Sujanthan, K Sunderland, R Swartz, B Tan, D Tang-Wai, C Tartaglia, A Troyer, J Turnbull, L Zinman, ONDRI Investigators (), DP Munoz
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- Journal:
- Canadian Journal of Neurological Sciences / Volume 49 / Issue s1 / June 2022
- Published online by Cambridge University Press:
- 24 June 2022, p. S8
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Background: Eye movements reveal neurodegenerative disease processes due to overlap between oculomotor circuitry and disease-affected areas. Characterizing oculomotor behaviour in context of cognitive function may enhance disease diagnosis and monitoring. We therefore aimed to quantify cognitive impairment in neurodegenerative disease using saccade behaviour and neuropsychology. Methods: The Ontario Neurodegenerative Disease Research Initiative recruited individuals with neurodegenerative disease: one of Alzheimer’s disease, mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson’s disease, or cerebrovascular disease. Patients (n=450, age 40-87) and healthy controls (n=149, age 42-87) completed a randomly interleaved pro- and anti-saccade task (IPAST) while their eyes were tracked. We explored the relationships of saccade parameters (e.g. task errors, reaction times) to one another and to cognitive domain-specific neuropsychological test scores (e.g. executive function, memory). Results: Task performance worsened with cognitive impairment across multiple diseases. Subsets of saccade parameters were interrelated and also differentially related to neuropsychology-based cognitive domain scores (e.g. antisaccade errors and reaction time associated with executive function). Conclusions: IPAST detects global cognitive impairment across neurodegenerative diseases. Subsets of parameters associate with one another, suggesting disparate underlying circuitry, and with different cognitive domains. This may have implications for use of IPAST as a cognitive screening tool in neurodegenerative disease.
The Recruitment Innovation Center: Developing novel, person-centered strategies for clinical trial recruitment and retention
- Consuelo H. Wilkins, Terri L. Edwards, Mary Stroud, Nan Kennedy, Rebecca N. Jerome, Colleen E. Lawrence, Sheila V. Kusnoor, Sarah Nelson, Loretta M. Byrne, Leslie R. Boone, Julia Dunagan, Tiffany Israel, Casey Rodweller, Bethany Drury, Rhonda G. Kost, Jill M. Pulley, Gordon R. Bernard, Paul A. Harris
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- Journal:
- Journal of Clinical and Translational Science / Volume 5 / Issue 1 / 2021
- Published online by Cambridge University Press:
- 19 August 2021, e194
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Clinical trials continue to face significant challenges in participant recruitment and retention. The Recruitment Innovation Center (RIC), part of the Trial Innovation Network (TIN), has been funded by the National Center for Advancing Translational Sciences of the National Institutes of Health to develop innovative strategies and technologies to enhance participant engagement in all stages of multicenter clinical trials. In collaboration with investigator teams and liaisons at Clinical and Translational Science Award institutions, the RIC is charged with the mission to design, field-test, and refine novel resources in the context of individual clinical trials. These innovations are disseminated via newsletters, publications, a virtual toolbox on the TIN website, and RIC-hosted collaboration webinars. The RIC has designed, implemented, and promised customized recruitment support for 173 studies across many diverse disease areas. This support has incorporated site feasibility assessments, community input sessions, recruitment materials recommendations, social media campaigns, and an array of study-specific suggestions. The RIC’s goal is to evaluate the efficacy of these resources and provide access to all investigating teams, so that more trials can be completed on time, within budget, with diverse participation, and with enough accrual to power statistical analyses and make substantive contributions to the advancement of healthcare.
Early Science from POSSUM: Shocks, turbulence, and a massive new reservoir of ionised gas in the Fornax cluster
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- C. S. Anderson, G. H. Heald, J. A. Eilek, E. Lenc, B. M. Gaensler, Lawrence Rudnick, C. L. Van Eck, S. P. O’Sullivan, J. M. Stil, A. Chippendale, C. J. Riseley, E. Carretti, J. West, J. Farnes, L. Harvey-Smith, N. M. McClure-Griffiths, Douglas C. J. Bock, J. D. Bunton, B. Koribalski, C. D. Tremblay, M. A. Voronkov, K. Warhurst
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 38 / 2021
- Published online by Cambridge University Press:
- 23 April 2021, e020
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We present the first Faraday rotation measure (RM) grid study of an individual low-mass cluster—the Fornax cluster—which is presently undergoing a series of mergers. Exploiting commissioning data for the POlarisation Sky Survey of the Universe’s Magnetism (POSSUM) covering a ${\sim}34$ square degree sky area using the Australian Square Kilometre Array Pathfinder (ASKAP), we achieve an RM grid density of ${\sim}25$ RMs per square degree from a 280-MHz band centred at 887 MHz, which is similar to expectations for forthcoming GHz-frequency ${\sim}3\pi$-steradian sky surveys. These data allow us to probe the extended magnetoionic structure of the cluster and its surroundings in unprecedented detail. We find that the scatter in the Faraday RM of confirmed background sources is increased by $16.8\pm2.4$ rad m−2 within 1$^\circ$ (360 kpc) projected distance to the cluster centre, which is 2–4 times larger than the spatial extent of the presently detectable X-ray-emitting intracluster medium (ICM). The mass of the Faraday-active plasma is larger than that of the X-ray-emitting ICM and exists in a density regime that broadly matches expectations for moderately dense components of the Warm-Hot Intergalactic Medium. We argue that forthcoming RM grids from both targeted and survey observations may be a singular probe of cosmic plasma in this regime. The morphology of the global Faraday depth enhancement is not uniform and isotropic but rather exhibits the classic morphology of an astrophysical bow shock on the southwest side of the main Fornax cluster, and an extended, swept-back wake on the northeastern side. Our favoured explanation for these phenomena is an ongoing merger between the main cluster and a subcluster to the southwest. The shock’s Mach angle and stand-off distance lead to a self-consistent transonic merger speed with Mach 1.06. The region hosting the Faraday depth enhancement also appears to show a decrement in both total and polarised radio emission compared to the broader field. We evaluate cosmic variance and free-free absorption by a pervasive cold dense gas surrounding NGC 1399 as possible causes but find both explanations unsatisfactory, warranting further observations. Generally, our study illustrates the scientific returns that can be expected from all-sky grids of discrete sources generated by forthcoming all-sky radio surveys.
Recommendations for Patients with Complex Nerve Injuries during the COVID-19 Pandemic
- Kristine M. Chapman, Michael J. Berger, Christopher Doherty, Dimitri J. Anastakis, Heather L. Baltzer, Kirsty Usher Boyd, Sean G. Bristol, Brett Byers, K. Ming Chan, Cameron J.B. Cunningham, Kristen M. Davidge, Jana Dengler, Kate Elzinga, Jennifer L. Giuffre, Lisa Hadley, A Robertson Harrop, Mahdis Hashemi, J. Michael Hendry, Kristin L. Jack, Emily M. Krauss, Timothy J. Lapp, Juliana Larocerie, Jenny C. Lin, Thomas A. Miller, Michael Morhart, Christine B. Novak, Russell O’Connor, Jaret L. Olsen, Benjamin R. Ritsma, Lawrence R. Robinson, Douglas C. Ross, Christiaan Schrag, Alexander Seal, David T. Tang, Jessica Trier, Gerald Wolff, Justin Yeung
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- Journal:
- Canadian Journal of Neurological Sciences / Volume 48 / Issue 1 / January 2021
- Published online by Cambridge University Press:
- 27 August 2020, pp. 50-55
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Efficacy of residual herbicides influenced by cover-crop residue for control of Amaranthus palmeri and A. tuberculatus in soybean
- Clay M. Perkins, Karla L. Gage, Jason K. Norsworthy, Bryan G. Young, Kevin W. Bradley, Mandy D. Bish, Aaron Hager, Lawrence E. Steckel
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- Weed Technology / Volume 35 / Issue 1 / February 2021
- Published online by Cambridge University Press:
- 20 July 2020, pp. 77-81
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Field studies were conducted in 2018 and 2019 in Arkansas, Indiana, Illinois, Missouri, and Tennessee to determine if cover-crop residue interfered with herbicides that provide residual control of Palmer amaranth and waterhemp in no-till soybean. The experiments were established in the fall with planting of cover crops (cereal rye + hairy vetch). Herbicide treatments consisted of a nontreated or no residual, acetochlor, dimethenamid-P, flumioxazin, pyroxasulfone + flumioxazin, pendimethalin, metribuzin, pyroxasulfone, and S-metolachlor. Palmer amaranth took 18 d and waterhemp took 24 d in the cover crop–alone (nontreated) treatment to reach a height of 10 cm. Compared with this treatment, all herbicides except metribuzin increased the number of days until 10-cm Palmer amaranth was present. Flumioxazin applied alone or in a mixture with pyroxasulfone were the best at delaying Palmer amaranth growing to a height of 10 cm (35 d and 33 d, respectively). The herbicides that resulted in the lowest Palmer amaranth density (1.5 to 4 times less) integrated with a cover crop were pyroxasulfone + flumioxazin, flumioxazin, pyroxasulfone, and acetochlor. Those four herbicide treatments also delayed Palmer amaranth emergence for the longest period (27 to 34 d). Waterhemp density was 7 to 14 times less with acetochlor than all the other herbicides present. Yield differences were observed for locations with waterhemp. This research supports previous research indicating that utilizing soil-residual herbicides along with cover crops improves control of Palmer amaranth and/or waterhemp.
2177 – Neuroanatomical Changes Associated With Subthreshold Depression In Adolescents
- H. Vulser, M.-L. Paillere-Martinot, H. Lemaitre, R. Miranda, E. Artiges, R. Goodman, J. Penttilä, M. Struve, T. Fadai, V. Kappel, L. Poustka, P. Conrod, T. Banaschewski, A. Barbot, G.J. Barker, C. Büchel, H. Flor, J. Gallinat, H. Garavan, A. Heinz, B. Ittermann, C. Lawrence, E. Loth, K. Mann, T. Paus, Z. Pausova, M. Rietschel, T.W. Robbins, M. Smolka, G. Schumann, J.-L. Martinot, IMAGEN Consortium
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- European Psychiatry / Volume 28 / Issue S1 / 2013
- Published online by Cambridge University Press:
- 15 April 2020, 28-E1340
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Introduction
Although neuroimaging studies suggest brain regional abnormalities in depressive disorders, it remains unclear whether abnormalities are present at illness onset or reflect disease progression.
ObjectivesWe hypothesized that cerebral variations were present in adolescents with subthreshold depression known to be at high risk for later full-blown depression.
AimsWe examined brain structural and diffusion-weighted magnetic resonance images of adolescents with subthreshold depression.
MethodsThe participants were extracted from the European IMAGEN study cohort of healthy adolescents recruited at age 14. Subthreshold depression was defined as a distinct period of abnormally depressed or irritable mood, or loss of interest, plus two or more depressive symptoms but without diagnosis of Major Depressive Episode. Comparisons were performed between adolescents meeting these criteria and control adolescents within the T1-weighted imaging modality (118 and 475 adolescents respectively) using voxel-based morphometry and the diffusion tensor imaging modality (89 ad 422 adolescents respectively) using tract-based spatial statistics. Whole brain analyses were performed with a statistical threshold set to p< 0.05 corrected for multiple comparisons.
ResultsCompared with controls, adolescents with subthreshold depression had smaller gray matter volume in caudate nuclei, medial frontal and cingulate cortices; smaller white matter volume in anterior limb of internal capsules, left forceps minor and right cingulum; and lower fractional anisotropy and higher radial diffusivity in the genu of corpus callosum.
ConclusionsThe findings suggest that adolescents with subthreshold depression have volumetric and microstructural gray and white matter changes in the emotion regulation frontal-striatal-limbic network.
On the dispersion of a drug delivered intrathecally in the spinal canal
- J. J. Lawrence, W. Coenen, A. L. Sánchez, G. Pawlak, C. Martínez-Bazán, V. Haughton, J. C. Lasheras
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- Journal of Fluid Mechanics / Volume 861 / 25 February 2019
- Published online by Cambridge University Press:
- 27 December 2018, pp. 679-720
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This paper investigates the transport of a solute carried by the cerebrospinal fluid (CSF) in the spinal canal. The analysis is motivated by the need for a better understanding of drug dispersion in connection with intrathecal drug delivery (ITDD), a medical procedure used for treatment of some cancers, infections and pain, involving the delivery of the drug to the central nervous system by direct injection into the CSF via the lumbar route. The description accounts for the CSF motion in the spinal canal, described in our recent publication (Sánchez et al., J. Fluid Mech., vol. 841, 2018, pp. 203–227). The Eulerian velocity field includes an oscillatory component with angular frequency $\unicode[STIX]{x1D714}$, equal to that of the cardiac cycle, and associated tidal volumes that are a factor $\unicode[STIX]{x1D700}\ll 1$ smaller than the total CSF volume in the spinal canal, with the small velocity corrections resulting from convective acceleration providing a steady-streaming component with characteristic residence times of order $\unicode[STIX]{x1D700}^{-2}\unicode[STIX]{x1D714}^{-1}\gg \unicode[STIX]{x1D714}^{-1}$. An asymptotic analysis for $\unicode[STIX]{x1D700}\ll 1$ accounting for the two time scales $\unicode[STIX]{x1D714}^{-1}$ and $\unicode[STIX]{x1D700}^{-2}\unicode[STIX]{x1D714}^{-1}$ is used to investigate the prevailing drug-dispersion mechanisms and their dependence on the solute diffusivity, measured by the Schmidt number $S$. Convective transport driven by the time-averaged Lagrangian velocity, obtained as the sum of the Eulerian steady-streaming velocity and the Stokes-drift velocity associated with the non-uniform pulsating flow, is found to be important for all values of $S$. By way of contrast, shear-enhanced Taylor dispersion, which is important for values of $S$ of order unity, is shown to be negligibly small for the large values $S\sim \unicode[STIX]{x1D700}^{-2}\gg 1$ corresponding to the molecular diffusivities of all ITDD drugs. Results for a model geometry indicate that a simplified equation derived in the intermediate limit $1\ll S\ll \unicode[STIX]{x1D700}^{-2}$ provides sufficient accuracy under most conditions, and therefore could constitute an attractive reduced model for future quantitative analyses of drug dispersion in the spinal canal. The results can be used to quantify dependences of the drug-dispersion rate on the frequency and amplitude of the pulsation of the intracranial pressure, the compliance and specific geometry of the spinal canal and the molecular diffusivity of the drug.
Outcomes and emergency medical services resource utilization among patients with syncope arriving to the emergency department by ambulance
- Lawrence Yau, Muhammad A. Mukarram, Soo-Min Kim, Kirtana Arcot, Kednapa Thavorn, Ian G. Stiell, Monica Taljaard, Brian H. Rowe, Marco L. A. Sivilotti, Venkatesh Thiruganasambandamoorthy
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- Canadian Journal of Emergency Medicine / Volume 21 / Issue 4 / July 2019
- Published online by Cambridge University Press:
- 21 November 2018, pp. 499-504
- Print publication:
- July 2019
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Objective
Syncope accounts for 1% of emergency department (ED) visits, yet few experience a serious adverse event (SAE). Two-thirds of syncope patients are transported to the ED by ambulance, placing considerable burden on emergency medical services (EMS), and many of these transports may be unnecessary. We estimated the proportion of syncope patients who fell into a low-risk category based on an ED diagnosis of vasovagal syncope and the absence of EMS intervention, hospitalization, or SAE.
MethodsWe conducted a multicentre prospective cohort study enrolling adult syncope patients transported to the ED by ambulance over 13 months. We collected demographics and EMS interventions, and followed patients for 30 days to identify all SAE, including death, dysrhythmia, myocardial infarction, aortic dissection, pulmonary embolism, subarachnoid hemorrhage, significant hemorrhage, and related procedural interventions.
ResultsOf 990 (67.2%) patients transported to the ED by ambulance, 121 had EMS interventions, 137 suffered 30-day SAE, 393 (39.7%; 95%CI 36.6, 42.8) were deemed low risk, 41 patients with vasovagal syncope were lost to follow-up, and 298 patients were diagnosed with non-vasovagal syncope. During transport, 121 (12.2%; 95%CI 10.2, 14.3) patients underwent some EMS intervention, and 137 (14.6%; 95%CI 12.4, 16.9) suffered SAEs within 30 days.
ConclusionAbout 40% of patients transported to the ED by ambulance are at low risk and may not benefit from paramedic care or transport to a hospital. A robust clinical decision tool would help identify patients safe for treat-and-release, diversion to alternative care, or rapid offload into low-acuity ED areas, potentially reducing EMS workload and cost.
Bacterial Stimulation by Carbamothioate Herbicides
- James G. Mueller, Horace D. Skipper, Ernest G. Lawrence, Ellis L. Kline
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- Weed Science / Volume 37 / Issue 3 / May 1989
- Published online by Cambridge University Press:
- 12 June 2017, pp. 424-427
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Laboratory studies enumerated butylate-, EPTC-, vernolate-, pebulate-, and cycloate-utilizing bacteria and actinomycetes in a Dothan loamy sand following repeated use of butylate, EPTC, or vernolate. Herbicide utilizers were isolated on a defined medium composed of minimal salts plus 200 mg/L herbicide as the primary carbon source plus 25 mg/L TTC as an indicator of organisms capable of metabolizing the herbicide substrates. Media inoculated with a butylate-history soil developed more TTC-red actinomycetes on the butylate-indicator agar than did media inoculated with a non-herbicide-history soil. Similarly, media inoculated with a vernolate-history soil developed more TTC-red bacteria on the vernolate-indicator agar. Cross-adaptation from vernolate to butylate and cycloate was evident, with inoculant from the vernolate-history soil exhibiting an increase in bacterial counts when butylate or cycloate was present as the primary carbon source. Likewise, previous butylate exposure corresponded with an increase in the number of vernolate- and pebulate-utilizing actinomycetes. Previous exposure to EPTC resulted in an increased population of butylate- and pebulate-utilizing actinomycetes.
Broadleaf signalgrass (Brachiaria platyphylla) interference in corn
- Jason L. Alford, Robert M. Hayes, G. Neil Rhodes, Jr., Lawrence E. Steckel, Thomas C. Mueller
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- Journal:
- Weed Science / Volume 53 / Issue 1 / February 2005
- Published online by Cambridge University Press:
- 20 January 2017, pp. 97-100
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Field research was conducted in Tennessee at two locations over 3 yr under no-tillage conditions to examine the interaction of broadleaf signalgrass and corn yield. Broadleaf signalgrass was killed at various time intervals during the growing season by applying postemergent glyphosate. Corn injury was avoided by the use of a glyphosate-tolerant variety. Yield reductions because of broadleaf signalgrass interference occurred with weed densities > 150 plants m−2 and when the corn and weeds emerged simultaneously. Corn had the ability to withstand broadleaf signalgrass presence up to 28 d after planting with no yield loss at all locations.
Effects of shading on common waterhemp (Amaranthus rudis) growth and development
- Lawrence E. Steckel, Christy L. Sprague, Aaron G. Hager, F. William Simmons, German A. Bollero
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- Weed Science / Volume 51 / Issue 6 / December 2003
- Published online by Cambridge University Press:
- 20 January 2017, pp. 898-903
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Common waterhemp is a significant weed problem in Midwestern cropping systems partly because of its potential for multiple emergence events during the growing season. The effects of shade and time of emergence on this weed have not been characterized. In the field, common waterhemp vegetative and reproductive growth were evaluated under different irradiance levels at two emergence times. In full sunlight a common waterhemp plant emerging in late May produced 720 g of biomass and over one million seeds, and a plant emerging in late June produced 350 g of biomass and over 730,000 seeds. Plant biomass and seed production were lower as irradiance levels were decreased to 40, 68, and 99% shade. Mortality was high for common waterhemp grown in 99% shade; however, surviving plants produced some viable seed. Common waterhemp plants grown under reduced irradiance had higher leaf area ratios and lower relative growth rates.
Common Waterhemp (Amaranthus rudis) Control in Corn (Zea mays) with Single Preemergence and Sequential Applications of Residual Herbicides
- Lawrence E. Steckel, Christy L. Sprague, Aaron G. Hager
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- Weed Technology / Volume 16 / Issue 4 / December 2002
- Published online by Cambridge University Press:
- 20 January 2017, pp. 755-761
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Control of common waterhemp in corn with chloroacetamide and dinitroaniline herbicides can be inconsistent. Common waterhemp control by dimethenamid, S-metalochlor, pendimethalin, and three formulations of acetochlor, applied alone or with atrazine as single preemergence (PRE) or sequential PRE followed by postemergence (POST) treatment, was determined. The manufacturer's suggested use rate (1 time) of PRE herbicides was compared with sequential applications (0.66 time PRE followed by 0.34 time POST) of herbicides. POST applications included dicamba to control emerged common waterhemp. Single and sequential herbicide applications controlled common waterhemp at least 98%, 28 d after planting (DAP). But herbicides applied sequentially were more effective than PRE treatments by 56 DAP. Encapsulated acetochlor formulations controlled common waterhemp at least 85% by 56 DAP regardless of application method. Sequential applications of S-metolachlor controlled common waterhemp greater than 83%. Atrazine improved common waterhemp control regardless of herbicide or application method 56 DAP. Sequential applications of dimethenamid or S-metolachlor alone or with atrazine were more effective than single PRE applications of these herbicides.
Meningococcal disease epidemiology in Australia 10 years after implementation of a national conjugate meningococcal C immunization programme
- G. L. LAWRENCE, H. WANG, M. LAHRA, R. BOOY, P. B. McINTYRE
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- Journal:
- Epidemiology & Infection / Volume 144 / Issue 11 / August 2016
- Published online by Cambridge University Press:
- 20 April 2016, pp. 2382-2391
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Australia implemented conjugate meningococcal C immunization in 2003 with a single scheduled dose at age 12 months and catch-up for individuals aged 2–19 years. Several countries have recently added one or more booster doses to their programmes to maintain disease control. Australian disease surveillance and vaccine coverage data were used to assess longer term vaccine coverage and impact on invasive serogroup C disease incidence and mortality, and review vaccine failures. Coverage was 93% in 1-year-olds and 70% for catch-up cohorts. In 10 years, after adjusting for changes in diagnostic practices, population invasive serogroup C incidence declined 96% (95% confidence interval 94–98) to 0·4 and 0·6 cases/million in vaccinated and unvaccinated cohorts, respectively. Only three serogroup C deaths occurred in 2010–2012 vs. 68 in 2000–2002. Four (<1/million doses) confirmed vaccine failures were identified in 10 years with no increasing trend. Despite published evidence of waning antibody over time, an ongoing single dose of meningococcal C conjugate vaccine in the second year of life following widespread catch-up has resulted in near elimination of serogroup C disease in all age groups without evidence of vaccine failures in the first decade since introduction. Concurrently, serogroup B incidence declined independently by 55%.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- Book:
- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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Resilience and corpus callosum microstructure in adolescence
- A. Galinowski, R. Miranda, H. Lemaitre, M.-L. Paillère Martinot, E. Artiges, H. Vulser, R. Goodman, J. Penttilä, M. Struve, A. Barbot, T. Fadai, L. Poustka, P. Conrod, T. Banaschewski, G. J. Barker, A. Bokde, U. Bromberg, C. Büchel, H. Flor, J. Gallinat, H. Garavan, A. Heinz, B. Ittermann, V. Kappel, C. Lawrence, E. Loth, K. Mann, F. Nees, T. Paus, Z. Pausova, J.-B. Poline, M. Rietschel, T. W. Robbins, M. Smolka, G. Schumann, J.-L. Martinot, the IMAGEN Consortium
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- Journal:
- Psychological Medicine / Volume 45 / Issue 11 / August 2015
- Published online by Cambridge University Press:
- 30 March 2015, pp. 2285-2294
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Background
Resilience is the capacity of individuals to resist mental disorders despite exposure to stress. Little is known about its neural underpinnings. The putative variation of white-matter microstructure with resilience in adolescence, a critical period for brain maturation and onset of high-prevalence mental disorders, has not been assessed by diffusion tensor imaging (DTI). Lower fractional anisotropy (FA) though, has been reported in the corpus callosum (CC), the brain's largest white-matter structure, in psychiatric and stress-related conditions. We hypothesized that higher FA in the CC would characterize stress-resilient adolescents.
MethodThree groups of adolescents recruited from the community were compared: resilient with low risk of mental disorder despite high exposure to lifetime stress (n = 55), at-risk of mental disorder exposed to the same level of stress (n = 68), and controls (n = 123). Personality was assessed by the NEO-Five Factor Inventory (NEO-FFI). Voxelwise statistics of DTI values in CC were obtained using tract-based spatial statistics. Regional projections were identified by probabilistic tractography.
ResultsHigher FA values were detected in the anterior CC of resilient compared to both non-resilient and control adolescents. FA values varied according to resilience capacity. Seed regional changes in anterior CC projected onto anterior cingulate and frontal cortex. Neuroticism and three other NEO-FFI factor scores differentiated non-resilient participants from the other two groups.
ConclusionHigh FA was detected in resilient adolescents in an anterior CC region projecting to frontal areas subserving cognitive resources. Psychiatric risk was associated with personality characteristics. Resilience in adolescence may be related to white-matter microstructure.
Contributors
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- By Agoston T. Agoston, Syed Z. Ali, Mahul B. Amin, Daniel A. Arber, Pedram Argani, Sylvia L. Asa, Rebecca N. Baergen, Zubair W. Baloch, Andrew M. Bellizzi, Kurt Benirschke, Allen Burke, Kenneth B. Calder, Karen L. Chang, Rebecca D. Chernock, Wang Cheung, Thomas V. Colby, Byron P. Croker, Ronald A. DeLellis, Edward F. DiCarlo, Ralph C. Eagle, Hormoz Ehya, Brett M. Elicker, Tarik M. Elsheikh, Robert E. Fechner, Linda D. Ferrell, Melina B. Flanagan, Douglas B. Flieder, Christopher S. Foster, Lillian Gaber, Karuna Garg, Kim R. Geisinger, Ryan M. Gill, Eric F. Glassy, David J. Glembocki, Zachary D. Goodman, Robert O. Greer, David J. Grignon, Gerardo E. Guiter, Kymberly A. Gyure, Ian S. Hagemann, Michael R. Henry, Jason L. Hornick, Ralph H. Hruban, Phyllis C. Huettner, Peter A. Humphrey, Olga B. Ioffe, Edward C. Klatt, Michael J. Klein, Ernest E. Lack, James N. Lampros, Lester J. Layfield, Robin D. LeGallo, Kevin O. Leslie, James S. Lewis, Virginia A. LiVolsi, Alberto M. Marchevsky, Anne Marie McNicol, Mitra Mehrad, Elizabeth Montgomery, Cesar A. Moran, Christopher A. Moskaluk, George J. Netto, G. Petur Nielsen, Robert D. Odze, Arthur S. Patchefsky, James W. Patterson, Elizabeth N. Pavlisko, John D. Pfeifer, Celeste N. Powers, Richard A. Prayson, Anja C. Roden, Victor L. Roggli, Andrew E. Rosenberg, Sherif Said, Margie A. Scott, Raja R. Seethala, Carlie S. Sigel, Jan F. Silverman, Bruce R. Smoller, Edward B. Stelow, Nora C. J. Sun, Mark W. Teague, Satish K. Tickoo, Thomas M. Ulbright, Paul E. Wakely, Jun Wang, Lawrence M. Weiss, Mark R. Wick, Howard H. Wu, Rhonda K. Yantiss, Charles Zaloudek, Yaxia Zhang, Xiaohui Sheila Zhao
- Edited by Mark R. Wick, University of Virginia, Virginia A. LiVolsi, University of Pennsylvania School of Medicine, John D. Pfeifer, Washington University School of Medicine, St Louis, Edward B. Stelow, University of Virginia, Paul E. Wakely, Jr
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- Silverberg's Principles and Practice of Surgical Pathology and Cytopathology
- Published online:
- 13 March 2015
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- 26 March 2015, pp vii-x
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Contributors
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- By Venkataraman Anantharaman, Philip D. Anderson, Christopher W. Baugh, J. Stephen Bohan, Kirsten Boyd, Matthias Brachmann, Peter R. Brown, Shelley Calder, David Callaway, Peter Cameron, Jody Crane, Meaghan Cussen, Christina Dempsey, Jonathan A. Edlow, Thomas Fleischmann, Robert L. Freitas, John D. Halamka, Manuel Hernandez, Cherri Hobgood, Jock Hoffman, Steven Horng, Kirk B. Jensen, Jennifer R. Johnson, Stephanie Kayden, Tasnim Khan, Daniel G. Kirkpatrick, James Lennon, Mary Leupold, Thom Mayer, J. Lawrence Mottley, Scott B. Murray, Deirdre Mylod, Larry A. Nathanson, Michael P. Pietrzak, Elke Platz, Nadeem Qureshi, Matthew M. Rice, Andrew Schenkel, Chet Schrader, Puneet Seth, Richard B. Siegrist, David Smith, Robert E. Suter, Carrie Tibbles, Sebastian N. Walker, Lee A. Wallis, Julie Welch, Leana S. Wen
- Edited by Stephanie Kayden, Philip D. Anderson, Robert Freitas, Elke Platz
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- Book:
- Emergency Department Leadership and Management
- Published online:
- 05 December 2014
- Print publication:
- 27 November 2014, pp ix-xii
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Asteroseismology from Dome A, Antarctica
- J. N. Fu, W. K. Zong, Y. Yang, A. Moore, M. C. B. Ashley, X. Q. Cui, L. L. Feng, X. F. Gong, J. S. Lawrence, D. Luong-Van, Q. Liu, C. R. Pennypacker, Z. H. Shang, J. W. V. Storey, L. Z. Wang, L. F. Wang, H. G. Yang, X. Y. Yuan, D. G. York, X. Zhou, Z. H. Zhu
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- Journal:
- Proceedings of the International Astronomical Union / Volume 9 / Issue S301 / August 2013
- Published online by Cambridge University Press:
- 18 February 2014, pp. 409-410
- Print publication:
- August 2013
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Gattini and CSTAR have been installed at Dome A, Antarctica, which provide time-series photometric data for a large number of pulsating variable stars. We present the study for several variable stars with the data collected with the two facilities in 2009 to demonstrate the scientific potential of observations from Dome A for asteroseismology.